WebJan 1, 2013 · The ubiquitously expressed BRD4, one of five mammalian bromodomain proteins, was first found associated with mitotic chromosomes and implicated in cell cycle control. 1 BRD4 is now recognized as a critical mediator of normal and disease functions through its interactions with both cellular and viral factors. 2 BRD4 plays a role in … WebDec 1, 2024 · BRD4 is a known driver of tumor growth via enhancement of transcription of oncogenes such as Myc. More recent evidence also suggests a role of BRD4 in T cells. …
Regulation of programmed cell death by Brd4 - PubMed
WebHowever, the PROTAC QCA570 which uses HYD276 as a ligand for BRD4 is efficient in the depletion of leukemia stem cells but without effect to normal hematopoietic stem cells … WebBRD4 exists in three isoforms BRD4L, BRD4Sa, and BRD4Sb that reportedly have distinct functions in gene transcription ( Wu et al., 2024 ). The C-terminal motif (CTM) is unique in BRD4L and not present in BRD4S and other BET proteins. thinktool oscilloscope
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WebBromodomain containing protein (BRD4) play a major role in the gene expression, both in normal cell and cancerous cell through direct interaction with acetylated lysine residue … WebFeb 15, 2024 · Among the dysregulated cytokines, interleukin-15 (IL-15) appears to be essential for lymphoma cell growth and plays a key pathogenic role in CTCL. 6 Strong IL-15 expression is a characteristic feature of CTCL. 7 In CTCL, IL-15 has been implicated in the recruitment of CD4 + memory T cells to the skin, induction of T-cell proliferation, and … WebFull gene name according to HGNC. Bromodomain containing 4. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. BRD4 (CAP, HUNK1, HUNKI, MCAP) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). Read more. Cancer-related genes. thinktool platinum hd