WebApr 10, 2024 · Liposarcoma (LPS) is one of the most common subtypes of sarcoma with a high recurrence rate. CENPF is a regulator of cell cycle, differential expression of which has been shown to be related with various cancers. However, the prognostic value of CENPF in LPS has not been deciphered yet. Using data from TCGA and GEO datasets, the … Bub1p comprises a conserved N-terminal region, a central non-conserved region and a C-terminal serine/threonine kinase domain. The N-terminal region mediates binding of Hs-BUB1 to the mitotic kinetochore protein blinkin (a protein also commonly referred to as AF15q14). The latter interaction is essential for … See more Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the BUB1 gene. Bub1 is a See more The protein kinase Bub1 possesses versatile and distinct functions during the cell cycle, mainly in the SAC and chromosome … See more Recently Bub1 has been identified as a negative regulator of CIMD. Depletion of Bub1 results in increased CIMD in order to avoid aneuploidy … See more • Human BUB1 genome location and BUB1 gene details page in the UCSC Genome Browser. See more In humans Bub1 accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. During See more Disturbed mitotic checkpoints are a common feature of many human cancers. More precisely, mutations in the spindle checkpoint can … See more • Mitosis • Cell Cycle See more
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WebJun 3, 2012 · ( h ) Bub1 is localized at kinetochores throughout the entire cell cycle in the asynchronous spc7-12E cells. Cnp3 is the fission yeast homologue of CENP-C. ( i – k ) The signal intensity of... WebMar 30, 2024 · We show that low concentrations of nocodazole delay cell division under the control of the previously identified mitotic checkpoint genes BUB1, BUB3, MAD1, and MAD2 and independently of BUB2. The same genes mediate the cell cycle delay induced in ctf13 mutants, limited for an essential kinetochore component. Our data suggest that a low ... caresource radiology
BUB1 and BUBR1: multifaceted kinases of the cell cycle
WebOct 1, 1997 · Mad2 and Bub1 proteins reside at kinetochores and mediate checkpoint arrest of the cell cycle. (a) During a normal mitosis, Mad2 and Bub1 localize to kinetochores in prophase and prometaphase. Once all chromosomes are attached to the spindle, cells proceed through anaphase. (b) Misaligned chromosomes signal spindle assembly … WebJan 3, 2024 · Transcriptome and proteome reveals host cell cycle checkpoint as antiviral target for SARS-CoV-2. a Log 2 fold change profiles of mRNA and protein levels of CDK1 (Cyclin-dependent kinase 1), CDK2 ... WebMar 1, 2024 · Polo-like kinase 1 (PLK1) is an essential cell-cycle regulator that is frequently overexpressed in various human cancers. To determine whether Plk1 overexpression drives tumorigenesis, we established transgenic mouse lines that … caresource psychoatry providers