2024 Cbyb6f1-tg hras 2jic tg/wt 转基因小鼠

Cbyb6f1-tg hras 2jic tg/wt 转基因小鼠

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August undefined, 2024

Web系統名 Strain ：CByB6F1-Tg(HRAS)2Jic (tg/wt) 動物種 Species ：Mouse 生育場 Facility ：富士生育場 (Fuji Breeding Facility) 飼料 Diet ：CA-1自由摂取 (ad libitum), 放射線滅菌(Irradiation sterilization) 収容数 Housing：群飼 Group (5 heads/cage) 性別 Sex ♂ 週齢 Age 4W 5W 6W 7W 8W 9W 10W N 20 20 20 20 20 20 20 WebDec 23, 2024 · CByB6F1-Tg(HRAS)2Jic (rasH2) transgenic mouse model has been developed as an alternative to the long-term studies (1.5years-lifetime) to predict the carcinogenic potential of chemicals [19]. This mouse model is characterized by multiple copies of the human c-Ha-ras oncogene and promoter in its genome [19]. The results of …

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WebThe 6-month Tg.rasH2 mouse carcinogenicity model provides an acceptable alternative to the 2-year carcinogenicity study in CD-1 mice. However, key questions related to the use of this model for testing antisense oligonucleotides (ASOs) include the similarity in the biologic response between mouse strains and the feasibility of using data from the CD-1 mouse … Web(CByB6F1-Tg(HRAS)2Jic) were obtained from CLEA Japan, Inc., Tokyo, Japan, or from Taconic Farms, Inc., Germantown, New York. Mice used in the range-finding and toxicokinetic (TK) studies were wt/wt and approximately 6 to 9 weeks old at study start. Mice used in the 6-monthcarcinogenicity studies were hemizygous and approximately 8 to 9 … northern beaches council contact email

CB6F1-TgN (RasH2) Semantic Scholar

Web• approve transgenic mouse alternatives on a case-by-A 6-month carcinogenicity study in rasH2 (CByB6F1-Tg(HRAS)2Jic) mice is accepted by regulatory agencies under ICH … WebMice: Wild Type CByB6F1- Tg(HRAS)2Jic 3 RESULTS 4 CONCLUSION Altogether, these results demonstrate that RasH2 males are considered to be sexually mature from 5-6 … how to ride streetcar in new orleans

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WebCByB6F1-Tg(HRAS)2Jic (þ/ hemizygous c-Ha-ras) mice, obtained from Taconic Farms (Germantown, NY), were used in all studies. The knock-in Tg element (human prototype … Web1,583 jobs available in Township of Fawn Creek, KS on Indeed.com. Apply to Cyn404-usa-feature, Legal Secretary, Driver and more! northern beaches council damaged binWebFeb 9, 2012 · A Comparison of Spontaneous Tumors in Tg.rasH2 Mice in 26-week Carcinogenicity Studies Conducted at a Single Test Facility during 2004 to 2012 and 2013 to 2024. Paranjpe MG, Belich JL ... Historical control data of spontaneous tumors in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice. Paranjpe MG, Elbekaei RH ... how to ride the bus in boston

"WebThe official nomenclature for the model is CByB6F1-Tg(HRAS)2Jic which is maintained by intercrossing C57BL/6JJic-Tg(HRAS)2Jic hemizygous male mice with BALB/cByJJic female mice. The littermates derived from these intercrosses are the transgenic rasH2-Tg animals with the tg/wt genotype, and the wild type rasH2-Wt animals with a wt/wt genotype. " - Cbyb6f1-tg hras 2jic tg/wt 转基因小鼠

Cbyb6f1-tg hras 2jic tg/wt 转基因小鼠

Tg.rasH2 Mice and not CByB6F1 Mice Should Be Used for …

WebIncidence of spontaneous non-neoplastic lesions in transgenic CByB6 F1-Tg(HRAS)2Jic mice. Paranjpe MG, Shah SA, Denton MD, Elbekai RH. Toxicol Pathol. 2013;41(8):1137-45. The rasH2 mouse model for assessing carcinogenic potential of pharmaceuticals. Nambiar PR, Morton D. Toxicol Pathol. 2013;41(8):1058-67. Webof spontaneous tumors in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice. Int J Toxicol. 2013 Jan-Feb;32(1):48-57. doi: 10.1177/1091581812471565. Epub 2013 Jan 16. 3. Paranjpe MG, Shah SA, Denton MD, Elbekai RH. Incidence of spontaneous non-neoplastic lesions in transgenic CBYB6F1-Tg(HRAS)2Jic

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WebFeb 19, 2013 · The rasH2 mouse, officially known as CByB6F1-Tg(HRAS)2Jic, is a hemizygous transgenic mouse carrying the human c-Ha-ras gene with its own … WebCB6F1-TgN (RasH2) Known as: CByB6F1-Tg (HRAS)2Jic. A transgenic mouse at F1 generation with background strain C57BL/6 crossed with BALB/cAn, containing three copies of the human c-Ha-Ras gene…. Expand. National Institutes of Health. Create Alert.

WebMar 7, 2024 · Explore Houston METRO transit services near you - local and Park & Ride bus routes, light rail lines, transit facilities, HOV lanes. Get started now. WebThe knock-in Tg element (human prototype c Ha-ras gene with its own promoter/enhancer) is injected into C57BL/6 × BALB/c F2 zygotes, which are crossed back to the C57BL/6J strain forming C57BL/6JJic-Tg(HRAS)2Jic. The CByB6F1-Tg(HRAS)2Jic (±hemizygous c-Ha-ras) is the offspring from a cross of the C57BL/6JJic-Tg(HRAS)2Jic hemizygous …

Web系統名 Strain ：CByB6F1-Tg（HRAS)2Jic（wt/wt）動物種 Species ：Mouse 生育場 Facility ：富士生育場 (Fuji Breeding Facility) 飼料 Diet ：CA-1自由摂取 (ad libitum), 放射線滅菌(Irradiation sterilization) 収容数 Housing：群飼 Group (5 heads/cage) 性別 Sex ♂ 週齢 Age 4W 5W 6W 7W 8W 9W 10W N 20 20 20 20 20 ... WebMice: Wild Type CByB6F1- Tg(HRAS)2Jic 3 RESULTS 4 CONCLUSION Altogether, these results demonstrate that RasH2 males are considered to be sexually mature from 5-6 weeks of age, on the basis of sperm count and histological data, with evidence of functional sexual maturity from 6-7 weeks of age. In females, histopathological evaluation did not ...

WebMay 1, 2024 · Tg.rasH2 or transgenic CByB6F1-Tg(HRAS)2Jic is a hemizygous mouse carrying at least 3 copies of the human c-Ha-ras gene in tandem with its own …

Web25 Homes For Sale in Fawnskin, CA. Browse photos, see new properties, get open house info, and research neighborhoods on Trulia. northern beaches council conservation zonesWebThe purpose of this publication is to present a large database pertaining to the non-neoplastic spontaneous lesions noted in Tg.rasH2 mice from studies conducted at our facility. Lesions that are considered unique in Tg.rasH2 mice are skeletal muscle myopathy, vascular anomalies involving various organs, and mesenteric arterial thrombosis. how to ride scooter first timeWebAbstract. The Tg.rasH2 mouse is a hemizygous transgenic mouse, approved by regulatory agencies for carcinogenicity assessment. However, the absence of a historical database … how to ride the el in chicagoWebBased on the analysis presented in this article, we propose that the Tg.rasH2 mice and not the CByB6F1 mice should be used in future DRF studies. The Tg.rasH2 mice … northern beaches council dog parksWebJan 31, 2024 · Transgenic (Humanized sequence, Inserted expressed sequence) Mutation details : Human HRAS genomic fragment containing 2.4 kb of 5'and 4.4 kb of 3' flanking … northern beaches council fees and chargesWebrasH2 mouse: reproducibility and stability of carcinogenicity due to a standardized production and monitoring system. northern beaches council customer serviceWebTaconic has received original stock for refresh in 2005, 2012, 2016, and 2024. The mice were derived by embryo transfer and are maintained by intercrossing C57BL/6JJic-Tg(HRAS)2Jic hemizygous male mice with … how to ride the ny subway