Hipsc-ccs
Webb1 maj 2024 · We generated confluent hiPSC-derived cardiac cell sheets (hiPSC-CCSs), expressing the genetically encoded voltage indicator ArcLight. ArcLight-based optical mapping allowed generation of... Webb9 okt. 2024 · “The hiPSC-CC exosomes are acellular and, consequently, may enable physicians to exploit the cardioprotective and reparative properties of hiPSC-derived cells while avoiding the complexities associated with tumorigenic risks, cell storage, transportation and immune rejection,” said Ling Gao, Ph.D., and Jianyi “Jay” Zhang, …
Hipsc-ccs
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Webb1 dec. 2024 · Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising tool for disease modeling and drug development. However, hiPSC-CMs remain functionally immature, which hinders their utility as a model of human cardiomyocytes. Objective To improve the electrophysiological maturation of hiPSC … WebbIn the field of cardiac electrophysiology, most studies examined the electrical properties of the hiPSC-derived cardiomyocytes (hiPSC-CMs) at the single-cell level, focusing primarily on action potential (AP) and ionic current characteristics.
Webb“Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine,” Recovery from experimental heart attacks can be improved with an injection of a mixture of heart muscle cells, endothelial cells and smooth muscle cells, but results are limited by poor ... Webb14 maj 2024 · Optical mapping of the SQTS-hiPSC-CCSs revealed shortened APD, impaired APD-rate adaptation, abbreviated wavelength of excitation, and increased inducibility of sustained spiral-waves. Phase-mapping analysis revealed accelerated and stabilized rotors manifested by increased rotor rotation frequency, increased rotor …
Webb29 sep. 2024 · “The hiPSC-CC exosomes are acellular and, consequently, may enable physicians to exploit the cardioprotective and reparative properties of hiPSC-derived … Webb30 sep. 2024 · Now research in pigs shows that using the exosomes naturally produced from that mixture of heart muscle cells, endothelial cells and smooth muscle cells—which were all derived from human induced pluripotent stem cells—yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells, or hiPSC …
WebbInherited arrhythmogenic syndromes, such as short QT syndrome (SQTS), were modeled using patient-specific hiPSCs. hiPSC-derived cardiac cell sheets (hiPSC-CCSs) were generated from a symptomatic SQTS patient carrying the N588K mutation in the KCNH2 gene and were used as a tool for studying conduction and arrhythmogenesis.
WebbThis paper describes the means for establishing an hiPSC-based model of CPVT in order to recapitulate the disease phenotype in vitro and investigate underlying … cottage white paintWebbCRISPR/Cas9-based mutation correction) control hiPSC-derived cardiomyocytes (hiPSC-CMs). Patch-clamp was used to evaluate action-potential (AP) and IKr current properties at the cellular level. Conduction and arrhythmogenesis were studied at the tissue level using confluent 2-dimensional hiPSC-derived cardiac cell sheets (hiPSC-CCSs) and optical cottage white doorsWebbConduction and arrhythmogenesis were studied at the tissue level using confluent 2-dimensional hiPSC-derived cardiac cell sheets (hiPSC-CCSs) and optical mapping. Results: Intracellular recordings demonstrated shortened action-potential duration (APD) and abbreviated refractory period in the SQTS-hiPSC-CMs. cottage white paint lowesWebb7 feb. 2024 · Two modes of Excitation-Contraction coupling in hiPSC-CMs. (A) Transient increase of intracellular Ca 2+ concentration and Ca 2+ diffusion in spontaneous (left) and paced (right) mode in silico measurements. The spatiotemporal representation is analogous to a line scan measurement in vitro. breathlessness dyspneaWebb想预览更多内容，点击免费在线预览全文 cottage white paint home depotWebb8 nov. 2024 · We present a large scale EP phenotyping system comprised of hiPSC-derived cardiac cell sheets (hiPSC-CCSs), fluorescent voltage sensors and actuators, … breathlessness going up stairsWebbMethodological approach. DMD-hiPSC lines from two Duchenne muscular dystrophy (DMD) patients were generated and analyzed compared to WT-hiPSC lines. DMD … breathlessness gp notebook