WebJhun and colleagues retrospectively analyzed 481 treatment-naive patients with MAC lung disease who started macrolide-based regimens ( 1 ). They identified 72 patients (15%) with refractory disease characterized by persistently positive sputum cultures despite ≥12 months of treatment. WebAug 20, 2024 · Respiratory infections with mycobacterium avium complex (MAC), one of the most common pathogens of nontuberculous mycobacterium pulmonary disease (NTM-PD), have been steadily increasing. Five-year survival of patients with MAC pulmonary disease (MAC-PD) also remains poor.
Amikacin Liposome Inhalation Suspension for Treatment …
WebThe American Thoracic Society improves global health by advancing research, patient care, and public health in pulmonary disease, critical illness, and sleep disorders. Founded in 1905 to combat TB, the ATS has grown to tackle asthma, COPD, lung cancer, sepsis, acute respiratory distress, and sleep apnea, among other diseases. WebDec 19, 2024 · A recent study showed that refractory MAC-PD was commonly caused by frequent reinfection with new MAC strains during antibiotic treatment rather than by persistence of the original strains, which could help to explain the infrequent development of macrolide resistance in patients with refractory MAC-PD46. dr gary lehrman northwell
Increasing and More Commonly Refractory Mycobacterium avium Pulmonary …
WebApr 14, 2024 · Patients with a diagnosis of treatment-refractory MAC lung disease consisting of all of the following (a) Microbiological, (b) Clinical, and (c) Radiographic criteria: Microbiological criteria: One Pre-Study MAC-positive respiratory specimen. Documentation of a MAC positive specimen collected per standard of care within 6 … WebRefractory MAC-LD is commonly caused by reinfection with new strains rather than persistence of the original strain, which may explain the infrequent development of macrolide resistance in refractory MAC-LD. The incidence and prevalence of nontuberculous mycobacterial lung disease (NTM-LD) are increasing worldwide ( 1, 2 ). enrichment services columbus georgia