2024 Thoc1 cancer

Thoc1 cancer

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August undefined, 2024

WebFeb 17, 2011 · THOC1, ALY and hSPT4 expression in paired normal/tumor tissues by cDNA array.(A) A Cancer Profiling Array II (Clontech), representing cDNA pools from matched … WebJul 15, 2013 · The expression of thoc1 was suppressed in bladder cancer cells (MBT-2) co-cultured with CCL-34-activated macrophages, whereas treatment with an iNOS inhibitor could restore the expression of thoc1. Direct treatment of MBT-2 cells with an NO donor also repressed thoc1 expression.

Andrographolide suppresses the malignancy of triple-negative …

WebMay 1, 2008 · The Thoc1 gene encodes a protein that binds the Rb N terminal domain. We hypothesize that some of Rb functions in vivo could be mediated in part by interaction with pThoc1. pThoc1 is an essential component of transcription export (TREX) complex and is required for early mouse embryonic development and the viability of transformed cells. WebJul 17, 2007 · The human Thoc1 gene, also known as hHpr1 or p84, encodes a protein that was originally identified as a nuclear matrix component that binds the retinoblastoma … tay k the race 10 hour

Functional significance of the Rb/Thoc1 interaction Cancer …

WebSep 1, 2009 · It seems Thoc1 is required for prostate tumorigenesis initiated by Rb1 and p53 mutation. Preliminary data suggest that Thoc1 may also be important in human prostate cancer. Because cancer cells seem to be particularly sensitive to Thoc1 loss, Thoc1 and the TREX complex may provide novel targets for cancer therapy. WebExpression of THOC1 (HPR1, P84) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. WebJul 15, 2013 · The expression of thoc1 was suppressed in bladder cancer cells (MBT-2) co-cultured with CCL-34-activated macrophages, whereas treatment with an iNOS inhibitor … the drop video

9984 - Gene ResultTHOC1 THO complex subunit 1 [ (human)]

THOC1 THO complex subunit 1 [ Homo sapiens (human) ]

WebNov 1, 2014 · Thoc1 protein expression in human prostate cancer.A) Tissue sections from resected human prostate cancer specimens were immunostained for pThoc1. A … WebTriple-negative breast cancers (TNBCs) are difficult to cure and currently lack of effective treatment strategies. Cancer stem cells (CSCs) are highly associated with the poor … tay k the race instrumental 1 hourWebThe THO complex 1 (Thoc1) is a nuclear matrix protein playing vital roles in transcription elongation and mRNA export. Recently, aberrant expression of Thoc1 has been reported in an increasing array of tumor types. However, the clinical significance of Thoc1 expression in colorectal cancer (CRC) is … tay k the race 1hr

"WebTHOC1 - Explore an overview of THOC1, with a histogram displaying coding mutations, full tabulated details of all associated variants, ... Mouse insertional mutagenesis … " - Thoc1 cancer

Thoc1 cancer

THOC1 THO complex subunit 1 [ Homo sapiens (human) ]

WebJul 15, 2013 · To determine whether the down-regulation of thoc1 plays an essential role in the CCL-34-induced macrophage-mediated cytotoxicity of cancer cells, several thoc1-overexpressing MBT-2 cell clones were established.A clone with a high expression level of thoc1 (designated as MBT-2/Thoc1#6) was chosen for subsequent experiments (Fig. 2 … WebSelect search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources

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WebPubMed WebDec 1, 2024 · Using a cell line system where R-loops were stabilized by depleting THOC1 or BRCA2, cells with increased R-loop levels were more sensitive to trabectedin treatment. Consistently, cancers that accumulate R-loops in the absence of BRCA1/2 or Fanconi anaemia proteins show higher sensitivity to trabectedin therapy [29, 30].

WebFeb 27, 2013 · The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase. ... Wang Y, Wang X, et al. (2007) Cancer cells and normal cells differ in their requirements for Thoc1. Cancer Research 67: 6657–6664. [Europe PMC free article] [Google Scholar] WebJul 15, 2013 · Notably, thoc1 overexpression attenuates andrographolide-suppressed cellular proliferation. Altogether, our results demonstrate that THOC1 promotes cancer stem cell characteristics of TNBC, and andrographolide is a potential natural compound for eliminating CSCs of TNBCs by downregulating the NF-κB-thoc1 axis.

WebDec 4, 2015 · The THO complex 1 (Thoc1) is a nuclear matrix protein playing vital roles in transcription elongation and mRNA export. Recently, aberrant expression of Thoc1 has …

WebLuteolin could reduce the expression of THOC1 and then increase the sensitivity of cisplatin to liver cancer, providing a new idea for drug therapy. 16 Downregulation of THOC1 or THOC5 did not induce apoptosis in normal cells but induces apoptosis in cancer cells, 40–42 which would make it possible to achieve the goal of drugs targeting only tumor cells.

WebDec 1, 2024 · 16 Downregulation of THOC1 or THOC5 did not induce 2710 apoptosis in normal cells but induces apoptosis in cancer cells, [40][41][42] which would make it possible to achieve the goal of drugs ... tay k - the race lyricsWebApr 9, 2024 · J Exp Clin Cancer Res, 2024 Jul 15. PMID 32669125, Free PMC Article; Elevated expression of Thoc1 is associated with aggressive phenotype and poor prognosis in colorectal cancer. Liu C, et al. Biochem Biophys Res Commun, 2015 Dec 4-11. PMID 26545775; Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in … thedrowners josefin instagramWebTHOC1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. tay k unreleased musicWebHepatocellular carcinoma (HCC) is one of the most common malignant cancers with poor prognosis and high incidence. The clinical data analysis of liver hepatocellular carcinoma samples downloaded from The Cancer Genome Atlas reveals that the THO Complex 1 (THOC1) is remarkable upregulated in HCC and associated with poor prognosis. However, … tay k the race gay lyricsWebTHOC1 (HPR1, P84) protein expression summary. We use cookies to enhance the usability of our website. ... BMC Cancer 2011;11:77: Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers Domínguez-Sánchez MS et al BMC Cancer 2011;11:77: ANTIGEN INFORMATION; tay k the race reactionWebJul 15, 2024 · Background: Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with poor prognosis and high incidence. The clinical data analysis of … tay k the race slowedWebTHO complex 1 (Thoc1) is a human nuclear matrix protein that binds to the retinoblastoma tumor suppressor retinoblastoma protein (pRb). While some studies suggest that Thoc1 … tay k the race 21 savage